E-Posters

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1. Examining Regeneration Capacity and Innervation of NMJs by iPSC-Derived Motor Neurons

By: Katherine Marshall

Additional Authors: Madison James, Labchan Rajbhandari, Arens Taga, Arun Venkatesan, Nicholas Maragakis, Mohamed Farah

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2. Clinical and genetic complexity among patients with the progressive mitochondrial neurodegenerative disease LHON-Plus

By: Anne Chiaramello

Additional Authors: Andrea Gropman, Eliana Gropman, Lisa Thompson, Martine Uittenbogaard

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3. Pharmacokinetics, Food Effect & Relative Bioavailability of Two Formulations of NBI-921352/XEN901 in Healthy Adults: Pediatric Granules & Adult Tablets

By: Gregory Beatch

Additional Authors: Rostam Namdari, Jay A. Cadieux, Gordon Loewen, Ernesto Aycardi

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4. Potential Drug-Drug Interactions Between NBI-921352/XEN901 (a Novel Nav1.6 Selective Sodium Channel Blocker) and a Strong Inducer of CYP3A4 (Phenytoin) in Healthy Volunteers 

By: Gordon Loewen

Additional Authors: Gregory Beatch, Jay Cadieux, Rostam Namdari, Ernesto Aycardi

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5. Utilizing Human Subjects Research Protection Trainings and Site Initiation Visits to Improve Participant Safety in Clinical Neurology Research

By: Matthew Gooden

Additional Authors: Gina Norato, Sandra Martin, Lauren Reoma

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6. Safety and Pharmacokinetics of Antisense Oligonucleotide STK-001 in Children and Adolescents with Dravet Syndrome: Design of the Open-Label Phase 1/2a MONARCH Study 

By: Javier Avendaño

Additional Authors: Linda Laux, Charlene Brathwaite, James Stutely, Nancy Wyant, Kimberly Parkerson, Barry Ticho

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7. NIH HEAL Initiative: NINDS Preclinical Screening Platform for Pain (PSPP) 

By: Sarah Woller

Additional Authors: Amir Tamiz, Mark Urban, Mark Varney, Emer Leahy, Taleen Hanania, Smriti Iyengar

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9. Establishment of a reversal learning assay in rats to investigate the effects of novel compounds on executive function

By: Fionn Dunphy-Doherty

Additional Authors: Danka Kozareva, Ewa Sokolowska , Jack Prenderville

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10. The NINDS Ultra-Rare Gene-based Therapy network: An URGenT need for ultra-rare neurological diseases

By: Ann-Marie Broome

Additional Authors: Nina Schor, Amir Tamiz, Jill Morris, Chris Boshoff, Mario Skiadopoulos, Julia Bachman, Genevieve Lind, Walter Koroshetz

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11. Efficacy & Safety of AXS-05, an Oral, NMDA Receptor Antagonist with Multimodal Activity in Major Depressive Disorder: Results from the ASCEND Phase 2, Double-blind, Active-controlled Trial

By: Amanda Jones

Additional Authors: Cedric O'Gorman, Mark Jacobson, Dan Iosifescu, Herriot Tabuteau

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12. Efficacy and Safety of AXS-05, an Oral, NMDA Receptor Antagonist with Multimodal Activity in Major Depressive Disorder: Results from the GEMINI Phase 3, Double-Blind, Placebo-Controlled Trial

By: Cedric O’Gorman

Additional Authors: Amanda Jones, Dan Iosifescu, Herriot Tabuteau

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13. Functional and Long-Term Survival Data of AMX0035 in Amyotrophic Lateral Sclerosis: Results of the CENTAUR Trial

By: Sabrina Paganoni

Additional Authors: Sean Healey,  Suzanne Hendrix, Samuel Dickson, Newman Knowlton, Joshua Cohen, Justin Klee, Kent Leslie, Rudolph Tanzi, Patrick Yeramian, Me...

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14. GM6 attenuates inflammation in Alzheimer’s disease pathology concurrently with reducing Beta Amyloid and phosphorylated tau

By: Mark Kindy

Additional Authors: Dorothy Ko

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15. AlzPED: Optimizing the Predictive Power of Drug Efficacy Studies in Alzheimer’s Disease Animal Models

By: Shreaya Chakroborty

Additional Authors: Ali Sharma, Zane Martin, Jean Yuan, Suzana Petanceska, Lorenzo Refolo

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16. Modulation of the p38 MAPK Pathway in Peripheral Blood Mononuclear Cells: Implications for Screening Novel Anti-Inflammatories in Alzheimer’s Disease 

By: Luke Davison

Additional Authors: Davison L, Duggan S, Downer E.J.,  Prenderville J.A.

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17. Dimethyl fumarate suppresses neurodegeneration through reduction of M1 macrophages-induced A1 reactive astrocytes and complement C3 deposition 

By: Sudhir Kumar Yadav

Additional Authors: Naoko Ito,  Devika Soin,  Kouichi Ito,  Suhayl Dhib-Jalbut

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18. Development of a Reconstituted Assay to Test Casein Kinase 1δ Inhibitors to Block Alzheimer’s Disease Progression 

By: Sabyasachi Chatterjee

Additional Authors: Angel’Niqua Dixon, Linh Tran, Breyanah Graham, Jumia Callaway, Phong Huynh, Jayalakshmi Sridhar, Thomas Huckaba

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19. Evaluation of novel non-opioid, non-addictive pain therapeutics within the NIH HEAL Initiative PSPP program- a case study 

By: Smriti Iyengar

Additional Authors:  Amir Tamiz,  Taleen Hanania, Emer Leahy, David Budac, Elizabeth Dugan, Mark Urban, Daniela Brunner, Herman Fernandes, Jodi Gresack, Qing C...

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20. Depression and Anhedonia: Acute Preclinical Efficacy for XEN1101, a Differentiated Kv7 Potassium Channel Modulator 

By: Alison Cutts

Additional Authors: Rostam Namdari, Greg Beatch, Nina Weishaupt, Richard Dean, Jeff Bechard, JP Johnson, James Empfield, Robin Sherrington

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21. Anticonvulsant Effects of the Differentiated Kv7 Channel Potentiator XEN1101 in Combination with Commonly Used Anti-Seizure Drugs

By: J.P. Johnson

Additional Authors: Girish Bankar, Celine Dube, Parisa Tari, Karen Nelkenbrecher, Matthew Waldbrook, Nina Weishaupt, Gregory Beatch, Jeff Bechard, Rostam Namd...

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22. The neutral sphingomyelinase 2 inhibitor PDDC reduces tau burden in Alzheimer’s disease mice

By: Carolyn Tallon

Additional Authors: Benjamin J. Bell, Medhinee Malvankar, Tawnjerae Joe, Kristen R. Hollinger, Ajit G. Thomas, Amrita Datta Chaudhuri, Ying Wu, Rana Rais, Nor...

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23. Sleep Disturbances in EcoHIV-infected Mice

By: Ben Bell

Additional Authors: Joshua Woo, Xiaolei Zhu, David Volsky, Mark Wu, Barbara Slusher

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24. Modulation of TREM2 Mechanism as a potential treatment for neurodegenerative diseases

By: Rafael Nir

Additional Authors:  Eliezer Zomer,  Olga Volpert,  Erez Eitan,  Elizabeth Griffith

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25. Targeted Inhibition of CDK5-mediated Regulation of Human Endogenous Retrovirus K Envelope Protein in Atypical Teratoid Rhabdoid Tumor 

By: Tara Doucet-O'Hare

Additional Authors: Jared Rosenblum,  Brianna DiSanza, Catherine DeMarino, Nasir Malik,  Joseph Steiner,  Abigail Atkinson,  Harish Pant,  Zhengping Zhuang,  Avindra...

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26. Neurophysiological Biomarkers of Dorsal and Ventral Subthalamic Nucleus in Parkinson’s Patients 

By: Jeffrey Nie

Additional Authors: Ahmad Elkouzi

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27. Impact of Neuregulin 1 Type III overexpression on motor axon development in Spinal Muscular Atrophy (SMA) model mice

By: Jeffrey Petigrow

Additional Authors: Cera Hassinan,  Lingling Kong, Michelle Harren Chan-Cortes,  Jannick Büttner,  Christian M. Simon,  Charlotte Sumner

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28. NINDS/Division of Translational Research-Funded Drug Discovery and Development Programs 

By: Mohamed Hachicha

Additional Authors: Charles Cywin, Amir Tamiz

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29. Securing bench to bedside translation with predictive EEG biomarkers of Parkinson's Disease

By: Venceslas Duveau

Additional Authors: Julien Volle, Chloé Habermacher, Alexis Evrard, Hedi Gharbi, Corinne Roucard, Yann Roche

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30. EEG Phenotyping as a tool to develop preclinical rodent models of brain disorders for identification and validation of new Neurotherapeutics

By: Corinne Roucard

Additional Authors: Venceslas Duveau, Julien Volle, Chloé Habermacher, Céline Ruggiero, Alexis Evrard, Yann Roche

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31. An fMRI study for discovering the resting-state functional changes in Schizophrenia using a statistical and ML-based approach 

By: Indranath Chatterjee

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32. Toward the use of paramagnetic rim lesions in proof-of-concept clinical trials for treating chronic inflammation in multiple sclerosis 

By: Jemima Akinsanya

Additional Authors: Martina Absinta, Nigar Dargah-zade, Erin S. Beck, Hadar Kolb,  Omar Al-Louzi, Pascal Sati, Govind Nair, Gina Norato, Karan D. Kawatra, Jeni...

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33. Optimizing Tilorone Analogs as Acetylcholinesterase Inhibitors Using Machine Learning and Recurrent Neural Networks

By: Ana Puhl

Additional Authors: Patricia A. Vignaux,  Eni Minerali,  Thomas R. Lane,  Daniel H. Foil,  Kimberley M. Zorn,  Fabio Urbina,  Jeremiah P. Malerich,  Dominique A. Tarta...

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34. Combined TMS/MRI with deep brain stimulation capability 

By: Dr. Irving Weinberg

Additional Authors: Oleg Udalov, Irving N. Weinberg, Ittai Baum, Cheng Chen, XinYao Tang, Micheal Petrillo, Roland Probst, Chase Seward, Sahar Jafari,  Pavel Y....

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35. The CURE Epilepsy Catalyst Award: Grant Opportunity For Translational Research in Epilepsy

By: Priya Balasubramanian

Additional Authors: Laura Lubbers

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36. Academic and Industry Physician Workforce Development in Experimental Neurotherapeutics

By: Shih Ludy

Additional Authors: Dietrich Haubenberger

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